Impact of donor/recipient body weight mismatch on allograft outcome in renal transplant recipients

Transplant Proc. Jan-Feb 2008;40(1):135-6. doi: 10.1016/j.transproceed.2007.11.029.

Abstract

Background: There have been conflicting reports that kidneys from small donors may be at risk for graft loss if they are transplanted into large recipients. The aim of this work was to examine the impact of donor/recipient body weight ratio (D/RBWR) on allograft outcome.

Patients and methods: Two hundred and seventeen kidney transplant recipients from living unrelated donor with 5-year follow-up underwent immunosuppression with cyclosporine, mycophenolate mofetil (or azathioprine), and prednisolone. According to the D/RBWR, the patients were divided into 3 groups: low (less than 0.8; G1), medium (0.81-1.1; G2), and high (more than 1.1; G3). We recorded 1-, 3-, and 5-year graft survivals, episodes of acute rejection, and mean serum creatinine values.

Results: Among the patients, 126 (58%) were female and the overall mean age was 41.62 years. There were no significant differences in 1-, 3-, and 5-year allograft survivals between the groups.

Conclusion: We concluded that low D/RBWR had no effect on short- or long-term renal allograft survival.

MeSH terms

  • Adult
  • Body Weight*
  • Creatinine / blood
  • Female
  • Follow-Up Studies
  • Graft Rejection / epidemiology
  • Graft Survival
  • Humans
  • Kidney Transplantation / physiology*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Time Factors
  • Tissue Donors*
  • Transplantation, Homologous
  • Treatment Outcome

Substances

  • Creatinine