IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

Nat Med. 2008 Mar;14(3):275-81. doi: 10.1038/nm1710. Epub 2008 Feb 10.

Abstract

Emerging evidence supports the concept that T helper type 17 (T(H)17) cells, in addition to mediating autoimmunity, have key roles in mucosal immunity against extracellular pathogens. Interleukin-22 (IL-22) and IL-17A are both effector cytokines produced by the T(H)17 lineage, and both were crucial for maintaining local control of the Gram-negative pulmonary pathogen, Klebsiella pneumoniae. Although both cytokines regulated CXC chemokines and granulocyte colony-stimulating factor production in the lung, only IL-22 increased lung epithelial cell proliferation and increased transepithelial resistance to injury. These data support the concept that the T(H)17 cell lineage and its effector molecules have evolved to effect host defense against extracellular pathogens at mucosal sites.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cells, Cultured
  • Chemokines / metabolism
  • Cystic Fibrosis / immunology
  • Cystic Fibrosis / pathology
  • Epithelial Cells / metabolism
  • Humans
  • Immunity, Mucosal / immunology*
  • Interleukin-17 / immunology
  • Interleukin-23 / immunology
  • Interleukins / immunology*
  • Interleukins / metabolism
  • Klebsiella Infections / immunology*
  • Klebsiella pneumoniae / immunology*
  • Klebsiella pneumoniae / metabolism
  • Lung / metabolism
  • Lung / microbiology
  • Lymph Nodes / cytology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Neutralization Tests
  • Receptors, Interleukin / genetics
  • Receptors, Interleukin / metabolism
  • Respiratory Mucosa / cytology
  • Spleen / microbiology
  • T-Lymphocytes / immunology
  • Up-Regulation

Substances

  • Chemokines
  • Interleukin-17
  • Interleukin-23
  • Interleukins
  • Receptors, Interleukin
  • interleukin-22 receptor
  • interleukin-22

Associated data

  • GEO/GSE10240