Firefly luminescence: a historical perspective and recent developments

Photochem Photobiol Sci. 2008 Feb;7(2):146-58. doi: 10.1039/b719181b. Epub 2008 Jan 23.


Significant advances have occurred regarding our knowledge of firefly luciferase mechanisms. Although most of this progress was an outcome of molecular biology and structural studies, important achievements have also occurred on its fundamental chemistry. Those developments are here summarized and presented in a historical perspective.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Fireflies / physiology*
  • Kinetics
  • Luciferases / chemistry
  • Luciferases / metabolism
  • Luminescence
  • Nucleosides / biosynthesis
  • Protein Conformation


  • Nucleosides
  • Luciferases