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, Chapter 9, Unit9.9

Overview of the Retrovirus Transduction System

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Overview of the Retrovirus Transduction System

C Cepko et al. Curr Protoc Mol Biol.

Abstract

A retrovirus vector is an infectious virus used to introduce a nonviral gene into mitotic cells in vivo or in vitro. The efficient and precise integration machinery of naturally occurring retroviruses is utilized to produce either a single copy or a few copies of the viral genome stably integrated into a host chromosome. This unit presents an overview of the retrovirus life cycle and a description of vector designs and packaging cell lines.

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