The effect of aminoguanidine on the blood-retinal barrier in streptozocin-induced diabetic rats

Ophthalmic Surg. 1991 Jan;22(1):44-7.


The effect of aminoguanidine hydrochloride (AG) on the blood-retinal barrier was studied in rats with streptozocin-induced diabetes. Half of the rats were given AG (100 mg/kg/day) while the remainder received no treatment. Vitreous fluorophotometry was performed on all rats before STZ injection and 2 weeks after induction of diabetes mellitus. Two weeks after STZ injection the mean 60-minute vitreous fluorescein concentration following dye injection had increased more in the nontreated group than in the AG-treated group, suggesting that AG may have some beneficial effect on the breakdown of the blood-retinal barrier.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blood Glucose / metabolism
  • Blood-Retinal Barrier*
  • Diabetes Mellitus, Experimental / chemically induced
  • Diabetes Mellitus, Experimental / metabolism*
  • Fluorophotometry
  • Guanidines / pharmacokinetics*
  • Male
  • Rats
  • Rats, Inbred Strains
  • Streptozocin
  • Vitreous Body / metabolism


  • Blood Glucose
  • Guanidines
  • Streptozocin
  • pimagedine