Experimental evidence for the efficacy of combined therapy of CPT-11 and hyperthermia for squamous cell carcinoma of the esophagus

Hepatogastroenterology. 2007 Dec;54(80):2272-5.


Background/aims: The aim of the current study was to show an anti-tumor effect for esophageal squamous carcinoma cells derived from a combination of hyperthermia and CPT-11, which would ultimately lead to the clinical usage of this therapeutic modality for patients with squamous cell carcinoma of the esophagus.

Methodology: Survival fraction of esophageal squamous carcinoma cells after administrating SN-38, active metabolite of CPT-11, and combination of hyperthermia and SN-38 was compared using data measured by MTT assay.

Results: Reduction of cell survival fraction derived by simultaneous induction of hyperthermia and SN-38, in many combinations of the temperature and charging period, was significantly greater than that acquired by SN-38 alone.

Conclusions: Combination of hyperthermia and CPT-11 can exert a synergic anti-tumor efficacy for SCC of the esophagus.

MeSH terms

  • Antineoplastic Agents, Phytogenic / therapeutic use*
  • Camptothecin / analogs & derivatives*
  • Camptothecin / therapeutic use
  • Carcinoma, Squamous Cell / drug therapy
  • Carcinoma, Squamous Cell / therapy*
  • Combined Modality Therapy
  • Esophageal Neoplasms / drug therapy
  • Esophageal Neoplasms / therapy*
  • Humans
  • Hyperthermia, Induced*
  • Irinotecan


  • Antineoplastic Agents, Phytogenic
  • Irinotecan
  • Camptothecin