Abnormal Pap smears in inflammatory bowel disease

Inflamm Bowel Dis. 2008 Aug;14(8):1158-60. doi: 10.1002/ibd.20391.


Inflammatory bowel disease (IBD) is a chronic inflammatory condition that is frequently treated with immunomodulators. Previous work has demonstrated an increased risk for abnormal cervical cytology in women treated with chronic immunosuppression, due mainly to human papillomavirus. This review summarizes the data known for this relationship in women with IBD, and management strategies for patients found to have abnormal cervical cytology.

Publication types

  • Review

MeSH terms

  • Cervical Intraepithelial Neoplasia / diagnosis
  • Cervical Intraepithelial Neoplasia / etiology*
  • Cervical Intraepithelial Neoplasia / therapy
  • Female
  • Humans
  • Immunocompromised Host
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / therapeutic use
  • Inflammatory Bowel Diseases / complications*
  • Inflammatory Bowel Diseases / drug therapy
  • Papanicolaou Test*
  • Risk Factors
  • Treatment Outcome
  • Uterine Cervical Dysplasia / diagnosis
  • Uterine Cervical Dysplasia / etiology*
  • Uterine Cervical Dysplasia / therapy
  • Uterine Cervical Neoplasms / diagnosis
  • Uterine Cervical Neoplasms / etiology*
  • Uterine Cervical Neoplasms / therapy
  • Vaginal Smears*


  • Immunosuppressive Agents