Ca(v)1 L-type Ca2+ channel signaling complexes in neurons

J Neurochem. 2008 May;105(3):573-83. doi: 10.1111/j.1471-4159.2008.05286.x. Epub 2008 Feb 7.


Ca(v)1 L-type Ca2+ channels play crucial and diverse roles in the nervous system. The pre- and post-synaptic functions of Ca(v)1 channels not only depend on their intrinsic biophysical properties but also their dynamic regulation by a host of cellular influences. These include protein kinases and phosphatases, G-protein coupled receptors, scaffolding proteins, and Ca2+-binding proteins. The cytoplasmic domains of the main pore forming alpha(1) subunit of Ca(v)1 offer a number of binding sites for these modulators, permitting fast and localized regulation of Ca2+ entry. Through effects on Ca(v)1 gating, localization, and coupling to effectors, protein modulators are efficiently positioned to adjust Ca(v)1 Ca2+ signals that control neuronal excitability, synaptic plasticity, and gene expression.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Binding Sites / physiology
  • Calcium Channels, L-Type / chemistry
  • Calcium Channels, L-Type / metabolism*
  • Calcium Signaling / physiology*
  • Cell Membrane / metabolism*
  • Humans
  • Ion Channel Gating / physiology
  • Nervous System / metabolism*
  • Neurons / metabolism*
  • Protein Structure, Tertiary / physiology
  • Synaptic Transmission / physiology


  • Calcium Channels, L-Type
  • L-type calcium channel alpha(1C)