The ubiquitin-proteasome system in Alzheimer's disease

J Cell Mol Med. 2008 Apr;12(2):363-73. doi: 10.1111/j.1582-4934.2008.00276.x. Epub 2008 Feb 8.


Accumulation of proteins is a recurring event in many neurodegenerative diseases, including Alzheimer's disease (AD). Evidence has suggested that protein accumulation may result from a dysfunction in the ubiquitin proteasome system (UPS). Indeed, there is clear genetic and biochemical evidence of an involvement of the ubiquitin proteasome system in AD. This review summarizes the data supporting an involvement of the UPS in the pathogenesis of AD, focusing on the data showing the relationship between Abeta and tau, the two hallmark lesions of AD, and the UPS.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alzheimer Disease / etiology*
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Amyloid beta-Peptides / metabolism
  • Models, Biological
  • Proteasome Endopeptidase Complex / physiology*
  • Protein Processing, Post-Translational
  • Ubiquitin / metabolism*
  • tau Proteins / metabolism


  • Amyloid beta-Peptides
  • Ubiquitin
  • tau Proteins
  • Proteasome Endopeptidase Complex