Dialogue between RhoA/ROCK and members of the Par complex in cell polarity

Dev Cell. 2008 Feb;14(2):150-2. doi: 10.1016/j.devcel.2008.01.015.

Abstract

Cell polarity is essential for many biological processes and is regulated by conserved protein complexes, including the Par complex, Rho GTPases, and their regulators. In this issue of Developmental Cell, studies by Nakayama et al. and Zhang and Macara examine how interplay between Rho GTPases and the Par complex control polarized cell migration and dendritic spine morphogenesis in alternate ways.

MeSH terms

  • Animals
  • Carrier Proteins / chemistry
  • Carrier Proteins / metabolism*
  • Cell Polarity*
  • Dendritic Spines / enzymology
  • Humans
  • Protein Kinase C / metabolism
  • Rats
  • cdc42 GTP-Binding Protein / metabolism
  • rho-Associated Kinases / metabolism*

Substances

  • Carrier Proteins
  • rho-Associated Kinases
  • PKC-3 protein
  • Protein Kinase C
  • cdc42 GTP-Binding Protein