Administration of 75 mg of aspirin daily for 28 days is sufficient prophylaxis against renal transplant vein thrombosis

Phlebology. 2007;22(2):83-5. doi: 10.1258/026835507780346187.

Abstract

Introduction: Early postoperative renal transplant vein thrombosis results in graft loss. We evaluate the effect of administering aspirin 75 mg daily for 28 days following transplantation.

Methods: Prospectively collected data on the outcome of all transplants undertaken in our unit in the five-year period from January 1997 to January 2002 were reviewed, and in cases of graft failure before three months the cause was defined.

Results: In the study period, a total of 401 transplants were undertaken (311 cadaveric and 90 living related). There was one case of renal transplant vein thrombosis (0.25%). This represents a significant reduction on the unit's historical incidence of 5.8%, P < 0.001.

Conclusion: Aspirin 75 mg daily is adequate to virtually abolish renal transplant vein thrombosis and has a role in thromboprophylaxis in other situations where heparin is contraindicated.

MeSH terms

  • Adult
  • Aged
  • Aspirin / administration & dosage*
  • Clinical Protocols
  • Drug Administration Schedule
  • Female
  • Fibrinolytic Agents / administration & dosage*
  • Graft Rejection / etiology
  • Graft Rejection / prevention & control*
  • Humans
  • Kidney Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Program Evaluation
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome
  • Venous Thrombosis / complications
  • Venous Thrombosis / etiology
  • Venous Thrombosis / prevention & control*

Substances

  • Fibrinolytic Agents
  • Aspirin