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, 130 (10), 2952-3

Stabilization of the Collagen Triple Helix by O-methylation of Hydroxyproline Residues

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Stabilization of the Collagen Triple Helix by O-methylation of Hydroxyproline Residues

Frank W Kotch et al. J Am Chem Soc.

Figures

Figure 1
Figure 1
CD spectroscopy and DSC data for peptides 1 and 2. (A) CD spectra of 1 (E) and 2 (J) (100 μM) at 4 °C in 50 mM HOAc (pH 3.0). (B) Thermal denaturation of 1 and 2 (200 μM) in 50 mM HOAc(aq) (E,J) and 2:1 EG/50 mM HOAc (pH 3.0) (Å,F). (C) DSC scans of 1 (231 μM) and 2 (129 μM) in 50 mM HOAc (pH 3.0); scan rate = 15 °C/h.
Figure 2
Figure 2
(A) Molecular drawing of crystalline Ac-Mop-OMe (50% probability ellipsoids). (B) Conformation of crystalline Ac-Mop-OMe and Ac-Hyp-OMe showing the putative nπ* interaction.

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