T cell subpopulations in the labial minor salivary gland histopathologic lesion of Sjögren's syndrome

J Rheumatol. 1991 Feb;18(2):210-4.


The majority of T cells constituting the focal lymphocytic infiltrates in the labial minor salivary glands of patients with Sjögren's syndrome bear the helper phenotype (CD4); activation is expressed by class II (HLA-DR) MHC products. In our immunohistologic study of snap frozen minor salivary gland biopsies from 16 patients with primary Sjögren's syndrome, it was shown that the majority (77%) of the infiltrating T cells exhibit the memory helper/inducer phenotype (UCHL-1) and express LFA-1 molecules. In addition most of the T cells express the alpha beta receptor while only 2.8% express the gamma delta receptor. Our findings suggest that these T cell infiltrates in patients with primary Sjögren's syndrome may explain the intense B lymphocyte hyperreactivity observed in the exocrine glands of patients with Sjögren's syndrome.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Antibodies, Monoclonal / immunology
  • B-Lymphocytes / immunology
  • B-Lymphocytes / metabolism
  • HLA-DR Antigens / immunology
  • HLA-DR Antigens / metabolism
  • Humans
  • Immunohistochemistry / methods
  • Lymphocyte Activation
  • Lymphocyte Function-Associated Antigen-1 / immunology
  • Lymphocyte Function-Associated Antigen-1 / metabolism
  • Middle Aged
  • Salivary Glands, Minor / immunology*
  • Salivary Glands, Minor / metabolism
  • Salivary Glands, Minor / pathology
  • Sjogren's Syndrome / immunology*
  • Sjogren's Syndrome / metabolism
  • Sjogren's Syndrome / pathology
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism
  • T-Lymphocytes, Helper-Inducer / immunology
  • T-Lymphocytes, Helper-Inducer / metabolism


  • Antibodies, Monoclonal
  • HLA-DR Antigens
  • Lymphocyte Function-Associated Antigen-1