Antifatigue Effects of Coenzyme Q10 During Physical Fatigue

Nutrition. 2008 Apr;24(4):293-9. doi: 10.1016/j.nut.2007.12.007. Epub 2008 Feb 13.

Abstract

Objective: This study examined the effects of coenzyme Q10 administration on physical fatigue.

Methods: In a double-blinded, placebo-controlled, three crossover design, 17 healthy volunteers were randomized to oral coenzyme Q10 (100 or 300 mg/d) or placebo administration for 8 d. As a fatigue-inducing physical task, subjects performed workload trials on a bicycle ergometer at fixed workloads twice for 2 h and then rested for 4 h. During the physical tasks, subjects performed non-workload trials with maximum velocity for 10 s at 30 min (30-min trial) after the start of physical tasks and 30 min before the end of the tasks (210-min trial).

Results: The change in maximum velocity from the 30- to the 210-min trial in the 300-mg coenzyme Q10-administered group was higher than that in the placebo group. In addition, subjective fatigue sensation measured on a visual analog scale in the 300-mg coenzyme Q10-administered group after the fatigue-inducing physical task and recovery period was alleviated when compared with that in the placebo group.

Conclusion: Oral administration of coenzyme Q10 improved subjective fatigue sensation and physical performance during fatigue-inducing workload trials and might prevent unfavorable conditions as a result of physical fatigue.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Bicycling / physiology*
  • Cross-Over Studies
  • Dose-Response Relationship, Drug
  • Double-Blind Method
  • Exercise Test
  • Female
  • Humans
  • Male
  • Muscle Fatigue / drug effects*
  • Muscle Fatigue / physiology
  • Physical Endurance / drug effects*
  • Physical Endurance / physiology
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / pharmacology
  • Vitamins / pharmacology*

Substances

  • Vitamins
  • Ubiquinone
  • coenzyme Q10