Maternal bisphenol-A levels at delivery: a looming problem?

J Perinatol. 2008 Apr;28(4):258-63. doi: 10.1038/ Epub 2008 Feb 14.


Objective: The objective was to determine whether bisphenol-A (BPA) is found in maternal circulation of pregnant women in the US population and is related to gestational length and birth weight.

Method: Circulating levels of BPA were quantified by high performance liquid chromatography-tandem mass spectrometry at delivery in 40 southeastern Michigan mothers and correlated with gestational length and birth weight of offspring.

Result: Maternal levels of unconjugated BPA ranged between 0.5 and 22.3 ng ml(-1) in southeastern Michigan mothers. There was no correlation between BPA concentrations and gestational length or birth weight of offspring.

Conclusion: This is the first study to document measurable levels of BPA in maternal blood of the US population. Long-term follow-up studies of offspring are needed to validate or refute concerns over human fetal exposure to synthetic exogenous steroids.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Benzhydryl Compounds
  • Birth Weight*
  • Body Height
  • Delivery, Obstetric
  • Estrogens, Non-Steroidal / blood*
  • Female
  • Humans
  • Infant, Newborn
  • Labor, Obstetric / blood*
  • Male
  • Michigan
  • Phenols / blood*
  • Pregnancy
  • Pregnancy Outcome*


  • Benzhydryl Compounds
  • Estrogens, Non-Steroidal
  • Phenols
  • bisphenol A