Effect of Siraitia grosvenorii polysaccharide on glucose and lipid of diabetic rabbits induced by feeding high fat/high sucrose chow

Exp Diabetes Res. 2007;2007:67435. doi: 10.1155/2007/67435.


The Siraitia grosvenorii polysaccharide (SGP) from the Siraitia grosvenorii (Swingle) was isolated and purified. The therapeutic effects of SGP on diabetic rabbits induced by feeding high fat/high sucrose chow were studied. After administration of SGP for 4 weeks, the fasting blood glucose (FBG), plasma insulin levels (INS), plasma total cholesterol (TC), triglyceride (TG), and HDL-C were assayed. The results showed that administration of SGP can significantly decrease plasma total cholesterol, triglyceride, and glucose levels; and increase HDL-C levels after 4 weeks of treatment. The antihyperglycaemic effect of SGP at dose of 100 mg.kg(-1) bw was the most significant in three dosage groups. Furthermore, SGP could restore the blood lipid levels of diabetic rabbits (P<.05). These data indicate that SGP not only ameliorates the lipid disorder, but also lowers plasma glucose levels. So SGP have obvious glucose-lowering effect on hyperglycaemic rabbits induced by feeding high fat/high sucrose chow, its mechanism may be related to amelioration of lipid metabolism and restoring the blood lipid levels of hyperglycaemic rabbits.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Feed / adverse effects
  • Animals
  • Blood Glucose / drug effects
  • Blood Glucose / metabolism*
  • Cucurbitaceae / chemistry*
  • Diabetes Mellitus, Experimental / chemically induced*
  • Diabetes Mellitus, Experimental / drug therapy*
  • Dietary Fats / adverse effects*
  • Lipids / blood*
  • Polysaccharides / pharmacology*
  • Rabbits
  • Sucrose / adverse effects*


  • Blood Glucose
  • Dietary Fats
  • Lipids
  • Polysaccharides
  • Sucrose