[Short duration of initial intravenous treatment in 70 pediatric patients with osteoarticular infections]

Rev Chilena Infectol. 2008 Feb;25(1):30-6. Epub 2008 Feb 8.
[Article in Spanish]


Osteoarticular infections (OAI) are infrequent in pediatrics and there is controversy on the need for prolonged use of intravenous antimicrobials.

Objective: To characterize and describe evolution and complications of a regimen of 7 days initial intravenous antibiotic treatment for OAI in children, completing 4-6 weeks of total treatment.

Patients and methods: In a large pediatric hospital, 70 children younger than 15 years of age were diagnosed with OAI between March 2003 and December 2004. Children received 7 days of intravenous antibiotics followed by 3 to 5 weeks of oral treatment.

Results: Incidence of OAI in this hospital was 1.8:10000. Patients mean age was 6.4 +/-4.4 years and 60% presented with septic arthritis, 36% osteomyelitis and 4% osteoarthritis. In 80% of cases, the infection was located in the lower extremity. Positive cultures were obtained in 59% predominating Staphylococcus aureus (46.5%). Seven patients had prolonged pain or persistently high or increasing serum C reactive protein levels and were maintained on prolonged intravenous therapy. None of the 63 children with 7 day intravenous antimicrobials nor the 7 children with prolonged intravenous use developed a complication in the short-term follow up.

Conclusions: Seven days of intravenous antibiotic for the initial phase of OAI treatment was effective in a majority of children and may be recommended.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Anti-Bacterial Agents / administration & dosage*
  • Arthritis, Infectious / drug therapy*
  • Ceftriaxone / administration & dosage
  • Child
  • Child, Preschool
  • Chloramphenicol / administration & dosage
  • Cloxacillin / administration & dosage
  • Drug Therapy, Combination
  • Female
  • Follow-Up Studies
  • Gram-Negative Bacteria / drug effects*
  • Gram-Positive Bacteria / drug effects*
  • Humans
  • Infant
  • Infusions, Intravenous
  • Male
  • Osteoarthritis / drug therapy*
  • Osteomyelitis / drug therapy*
  • Treatment Outcome


  • Anti-Bacterial Agents
  • Chloramphenicol
  • Ceftriaxone
  • Cloxacillin