Nephrin AKTs on Actin: The Slit Diaphragm-Actin Cytoskeleton Signaling Network Expands

Kidney Int. 2008 Mar;73(5):524-6. doi: 10.1038/sj.ki.5002741.

Abstract

Regulation and maintenance of the actin cytoskeleton of podocytes has emerged as a critical process for preserving glomerular permselectivity. Signaling through nephrin, a crucial component of the slit diaphragm, can lead to rearrangement of the actin cytoskeleton. Zhu et al. identify phosphoinositide 3-kinase-dependent activation of Akt and Rac as mediators of nephrin-induced actin reorganization, expanding the signaling network linking two of the podocyte's unique structures, its actin cytoskeleton and the slit diaphragm.

Publication types

  • Comment

MeSH terms

  • Actins / metabolism*
  • Animals
  • Cell Adhesion*
  • Cytoskeleton / metabolism*
  • Membrane Proteins / metabolism*
  • Phosphatidylinositol 3-Kinases / metabolism
  • Podocytes / metabolism*
  • Podocytes / ultrastructure
  • Proto-Oncogene Proteins c-akt / metabolism
  • Rats
  • Signal Transduction

Substances

  • Actins
  • Membrane Proteins
  • nephrin
  • Phosphatidylinositol 3-Kinases
  • Proto-Oncogene Proteins c-akt