A putative role for apelin in the etiology of obesity

Biochem Biophys Res Commun. 2008 Apr 11;368(3):815-9. doi: 10.1016/j.bbrc.2008.02.008. Epub 2008 Feb 12.


Apelin, the endogenous ligand of the G protein-coupled APJ receptor has been shown to promote tumor angiogenesis. However, the effect of apelin on inducing angiogenesis in adipose tissue has not been investigated. In this review, we propose a putative role for apelin in promoting angiogenesis in adipose tissue. We further propose that targeting adipose tissue vasculature by blocking apelin signaling with anti-apelin antibodies will lead not only to inhibition of angiogenesis in adipose tissue but also to decreased adiposity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipose Tissue / blood supply*
  • Adipose Tissue / metabolism*
  • Animals
  • Apelin
  • Humans
  • Intercellular Signaling Peptides and Proteins / metabolism*
  • Models, Biological*
  • Neovascularization, Pathologic / metabolism*
  • Obesity / etiology*
  • Obesity / metabolism*


  • APLN protein, human
  • Apelin
  • Intercellular Signaling Peptides and Proteins