Proteomics and diagnostics: Let's Get Specific, again

Curr Opin Chem Biol. 2008 Feb;12(1):78-85. doi: 10.1016/j.cbpa.2008.01.016. Epub 2008 Mar 7.


DNA array technology has changed all discussions about proteomics. Whole genome arrays allow unbiased experimentation, and the surprises that flow from those approaches. 'Whole proteome' proteomics is not possible today, and might never be possible unless experiments are guided by careful evaluation of reagent specificity. In this paper we explore some possible ways to increase the content of proteomic analysis.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies / immunology
  • Aptamers, Peptide / metabolism
  • Diagnosis*
  • Humans
  • Protein Array Analysis
  • Proteomics / methods*
  • Sensitivity and Specificity


  • Antibodies
  • Aptamers, Peptide