Protein targeting to ATP-dependent proteases

Curr Opin Struct Biol. 2008 Feb;18(1):43-51. doi: 10.1016/ Epub 2008 Feb 13.


ATP-dependent proteases control diverse cellular processes by degrading specific regulatory proteins. Recent work has shown that protein substrates are specifically transferred to ATP-dependent proteases through different routes. These routes can function in parallel or independently. In all of these targeting mechanisms, it can be useful to separate two steps: substrate binding to the protease and initiation of degradation.

Publication types

  • Review

MeSH terms

  • ATP-Dependent Proteases / chemistry*
  • ATP-Dependent Proteases / metabolism*
  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Binding Sites
  • Humans
  • Models, Biological
  • Models, Molecular
  • Proteasome Endopeptidase Complex / metabolism
  • Protein Folding
  • Protein Transport*
  • Substrate Specificity
  • Ubiquitin / metabolism


  • Adaptor Proteins, Signal Transducing
  • Ubiquitin
  • ATP-Dependent Proteases
  • Proteasome Endopeptidase Complex