Focal segmental glomerulosclerosis: recent advances

Curr Opin Nephrol Hypertens. 2008 Mar;17(2):138-42. doi: 10.1097/MNH.0b013e3282f5dbe4.


Purpose of review: Focal segmental glomerulosclerosis is a significant and growing cause of chronic kidney disease and nephrotic syndrome in adults and children.

Recent findings: The last year has seen continued progress in understanding podocyte biology, mechanisms of podocyte dysfunction, and its contribution to proteinuria and focal segmental glomerulosclerosis.

Summary: A number of studies have helped to elucidate the mechanisms of slit-diaphragm-mediated signaling to the podocyte cytoskeleton. Advances in treatment continue to lag behind advances in understanding focal segmental glomerulosclerosis disease biology.

Publication types

  • Review

MeSH terms

  • Animals
  • Cytoskeleton / pathology
  • Disease Models, Animal
  • Disease Progression
  • Genetic Predisposition to Disease
  • Glomerular Filtration Rate
  • Glomerulosclerosis, Focal Segmental* / complications
  • Glomerulosclerosis, Focal Segmental* / genetics
  • Glomerulosclerosis, Focal Segmental* / pathology
  • Glomerulosclerosis, Focal Segmental* / physiopathology
  • Glomerulosclerosis, Focal Segmental* / therapy
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics
  • Membrane Proteins / genetics
  • Nephrotic Syndrome / genetics
  • Nephrotic Syndrome / pathology
  • Podocytes / pathology
  • Risk Factors
  • Treatment Outcome


  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • NPHS2 protein