Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

Cell. 1991 May 17;65(4):701-13. doi: 10.1016/0092-8674(91)90101-4.


Three mouse cyclin-like (CYL) genes were isolated, two of which are regulated by colony-stimulating factor 1 (CSF-1) during the G1 phase of the macrophage cell cycle. CSF-1 deprivation during G1 leads to rapid degradation of CYL proteins (p36CYL) and correlates with failure to initiate DNA synthesis. However, after entering S phase, macrophages no longer require CSF-1 and can complete cell division without expressing CYL genes. During G1, p36CYL is phosphorylated and associates with a polypeptide antigenically related to p34cdc2. The timing of p36CYL expression, its rapid turnover in the absence of CSF-1, and its phosphorylation and transient binding to a cdc2-related polypeptide suggest that CYL genes may function during S phase commitment.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cell Cycle
  • Cell Line
  • Cloning, Molecular
  • Cyclins / genetics*
  • G1 Phase*
  • Gene Expression Regulation*
  • Gene Library
  • Kinetics
  • Macrophage Colony-Stimulating Factor / pharmacology*
  • Macrophages / cytology
  • Macrophages / drug effects
  • Macrophages / physiology*
  • Mice
  • Molecular Sequence Data
  • Multigene Family*
  • Sequence Homology, Nucleic Acid


  • Cyclins
  • Macrophage Colony-Stimulating Factor

Associated data

  • GENBANK/M64403