A new sesquiterpene and other terpenoid constituents of Chisocheton penduliflorus

Arch Pharm Res. 2008 Jan;31(1):21-7. doi: 10.1007/s12272-008-1115-8.

Abstract

A new aromadendrane sesquiterpene, allo-aromadendrane-10alpha, 14-diol (3), was isolated from Chisocheton penduliflorus (Meliaceae), along with two known sesquiterpenes: allo-aromadendrane-10beta, 14-diol (2) and allo-aromadendrane-10beta, 13, 14-triol (7). Six dammarane triterpenoids, including cabraleadiol (1), eichlerialactone (4), cabraleahydroxylactone (5), cabralealactone (6), hollongdione (8) and dammaradienone (9), the coumarins scoparone and scopoletin, and vanillic acid were also isolated from the wood and leaves of this plant. Compounds 1-7 displayed antimycobacterial activity against Mycobacterium tuberculosis. Compounds 1, 4, 5 and 6 were weakly cytotoxic to a breast cancer (BC) cell line; whereas, compound 6 was moderately active against a small-cell lung cancer (NCI-H187) cell line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Chemical Phenomena
  • Chemistry, Physical
  • Chromatography, Thin Layer
  • Drug Screening Assays, Antitumor
  • Humans
  • Mass Spectrometry
  • Meliaceae / chemistry*
  • Microbial Sensitivity Tests
  • Molecular Conformation
  • Mycobacterium tuberculosis / drug effects
  • Plant Leaves / chemistry
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology*
  • Sesquiterpenes, Guaiane
  • Spectrophotometry, Infrared
  • Spectroscopy, Fourier Transform Infrared
  • Terpenes / isolation & purification*
  • Terpenes / pharmacology*
  • Wood / analysis

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents, Phytogenic
  • Sesquiterpenes
  • Sesquiterpenes, Guaiane
  • Terpenes
  • allo-aromadendrane-10alpha,14-diol