Preventing intraperitoneal adhesions with vitamin E and sodium hyaluronate/carboxymethylcellulose: a comparative study in rats

Acta Cir Bras. Jan-Feb 2008;23(1):36-41. doi: 10.1590/s0102-86502008000100007.

Abstract

Purpose: To compare the effectiveness of intraperitoneally administered vitamin E with the sodium hyaluronate/carboxymethylcellulose membrane (HA/CBMC) in preventing postoperative intraperitoneal adhesion formation.

Methods: Sixty Wistar rats underwent a laparotomy and adhesions were induced (IA). The animals were divided into four groups: group 1, control (IA); group 2 (IA + Vitamin E): group 3 (IA+HA/CBMC) and group 4 (IA+ Vitamin E + HA/CBMC). The Vitamin E (groups 2 and 4) and HA/CBMC (groups 3 and 4) were administered intraperitoneally before the abdominal wall was closed. After 30 days, adhesions were classified by an independent surgeon.

Results: Three animals died; one from group 3 and two from group 4. All control animals had substantial adhesions compared with unsubstantial adhesions observed in 11/15 in group 2 (P = 0.000), 11/14 in group 3 (P = 0.001), and 10/13 in group 4 (P = 0.000).

Conclusion: Vitamin E, administered intraperitoneally, is as effective as HA/CBMC in preventing postoperative adhesions.

MeSH terms

  • Animals
  • Antioxidants / administration & dosage*
  • Carboxymethylcellulose Sodium / administration & dosage*
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Hyaluronic Acid / administration & dosage*
  • Injections, Intraperitoneal
  • Male
  • Peritoneal Diseases / pathology
  • Peritoneal Diseases / prevention & control*
  • Postoperative Complications / pathology
  • Postoperative Complications / prevention & control*
  • Rats
  • Rats, Wistar
  • Tissue Adhesions / prevention & control
  • Vitamin E / administration & dosage*

Substances

  • Antioxidants
  • Vitamin E
  • Hyaluronic Acid
  • Carboxymethylcellulose Sodium