Semaphorins deployed to repel cell migrants at spinal cord borders

J Biol. 2008;7(2):4. doi: 10.1186/jbiol65.


In the spinal cord, developing motor neurons extend their axons into the periphery while their cell bodies remain within the motor columns in the spinal cord. Two recent papers show that this partitioning involves forward and reverse semaphorin-plexin signaling between motor neurons and neural crest boundary cap cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement / physiology*
  • Humans
  • Neurons / cytology
  • Neurons / physiology
  • Semaphorins / physiology*
  • Signal Transduction / physiology
  • Spinal Cord / cytology*
  • Spinal Cord / physiology*


  • Semaphorins