A systems view of Drosophila segmentation

doi:10.1186/gb-2008-9-2-207

Review

. 2008;9(2):207.

doi: 10.1186/gb-2008-9-2-207. Epub 2008 Feb 11.

A systems view of Drosophila segmentation

Mike Levine¹

Affiliations

Affiliation

¹ Department of Molecular and Cell Biology, Division of Genetics, Genomics and Development, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA. mlevine@berkeley.edu

PMID: 18279540
PMCID: PMC2374715
DOI: 10.1186/gb-2008-9-2-207

Review

A systems view of Drosophila segmentation

Mike Levine. Genome Biol. 2008.

. 2008;9(2):207.

doi: 10.1186/gb-2008-9-2-207. Epub 2008 Feb 11.

Author

Mike Levine¹

Affiliation

¹ Department of Molecular and Cell Biology, Division of Genetics, Genomics and Development, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA. mlevine@berkeley.edu

PMID: 18279540
PMCID: PMC2374715
DOI: 10.1186/gb-2008-9-2-207

Abstract

High-throughput technologies have enabled the systematic identification and characterization of most, or possibly all, of the components governing segmentation in the fruit fly Drosophila. What have we learned?

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References

1. Clyde DE, Corado MS, Wu X, Paré A, Papatsenko D, Small S. A self-organizing system of repressor gradients establishes segmental complexity in Drosophila. Nature. 2003;426:849–853. doi: 10.1038/nature02189. - DOI - PubMed
1. Segal E, Raveh-Sadka T, Schroeder M, Unnerstall U, Gaul U. Predicting expression patterns from regulatory sequence in Drosophila segmentation. Nature. 2008. doi:10.1038/nature06496. - PubMed
1. Berman BP, Nibu Y, Pfeiffer BD, Tomancak P, Celniker SE, Levine M, Rubin GM, Eisen MB. Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome. Proc Natl Acad Sci USA. 2002;99:757–762. doi: 10.1073/pnas.231608898. - DOI - PMC - PubMed
1. Berman BP, Pfeiffer BD, Laverty TR, Salzberg SL, Rubin GM, Eisen MB, Celniker SE. Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura. Genome Biol. 2004;5:R61. doi: 10.1186/gb-2004-5-9-r61. - DOI - PMC - PubMed
1. Schroeder MD, Pearce M, Fak J, Fan H, Unnerstall U, Emberly E, Rajewsky N, Siggia ED, Gaul U. Transcriptional control in the segmentation gene network of Drosophila. PLoS Biol. 2004;2:1396–1410. doi: 10.1371/journal.pbio.0020271. - DOI - PMC - PubMed

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[1] Clyde DE, Corado MS, Wu X, Paré A, Papatsenko D, Small S. A self-organizing system of repressor gradients establishes segmental complexity in Drosophila. Nature. 2003;426:849–853. doi: 10.1038/nature02189. - DOI - PubMed

[2] Clyde DE, Corado MS, Wu X, Paré A, Papatsenko D, Small S. A self-organizing system of repressor gradients establishes segmental complexity in Drosophila. Nature. 2003;426:849–853. doi: 10.1038/nature02189. - DOI - PubMed

[3] Segal E, Raveh-Sadka T, Schroeder M, Unnerstall U, Gaul U. Predicting expression patterns from regulatory sequence in Drosophila segmentation. Nature. 2008. doi:10.1038/nature06496. - PubMed

[4] Segal E, Raveh-Sadka T, Schroeder M, Unnerstall U, Gaul U. Predicting expression patterns from regulatory sequence in Drosophila segmentation. Nature. 2008. doi:10.1038/nature06496. - PubMed

[5] Berman BP, Nibu Y, Pfeiffer BD, Tomancak P, Celniker SE, Levine M, Rubin GM, Eisen MB. Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome. Proc Natl Acad Sci USA. 2002;99:757–762. doi: 10.1073/pnas.231608898. - DOI - PMC - PubMed

[6] Berman BP, Nibu Y, Pfeiffer BD, Tomancak P, Celniker SE, Levine M, Rubin GM, Eisen MB. Exploiting transcription factor binding site clustering to identify cis-regulatory modules involved in pattern formation in the Drosophila genome. Proc Natl Acad Sci USA. 2002;99:757–762. doi: 10.1073/pnas.231608898. - DOI - PMC - PubMed

[7] Berman BP, Pfeiffer BD, Laverty TR, Salzberg SL, Rubin GM, Eisen MB, Celniker SE. Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura. Genome Biol. 2004;5:R61. doi: 10.1186/gb-2004-5-9-r61. - DOI - PMC - PubMed

[8] Berman BP, Pfeiffer BD, Laverty TR, Salzberg SL, Rubin GM, Eisen MB, Celniker SE. Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura. Genome Biol. 2004;5:R61. doi: 10.1186/gb-2004-5-9-r61. - DOI - PMC - PubMed

[9] Schroeder MD, Pearce M, Fak J, Fan H, Unnerstall U, Emberly E, Rajewsky N, Siggia ED, Gaul U. Transcriptional control in the segmentation gene network of Drosophila. PLoS Biol. 2004;2:1396–1410. doi: 10.1371/journal.pbio.0020271. - DOI - PMC - PubMed

[10] Schroeder MD, Pearce M, Fak J, Fan H, Unnerstall U, Emberly E, Rajewsky N, Siggia ED, Gaul U. Transcriptional control in the segmentation gene network of Drosophila. PLoS Biol. 2004;2:1396–1410. doi: 10.1371/journal.pbio.0020271. - DOI - PMC - PubMed

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A systems view of Drosophila segmentation

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A systems view of Drosophila segmentation

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