The status and role of ErbB receptors in human cancer

Exp Mol Pathol. 2008 Apr;84(2):79-89. doi: 10.1016/j.yexmp.2007.12.002. Epub 2008 Jan 5.


Changes in the expression of cellular receptors contribute to the progression of many types of solid tumors. In this review, we focus on the normal role of ErbB receptors as signal transducers and their contribution to carcinogenesis when there are abnormalities in ErbB signaling due to the overactivity of the receptors or the overexpression of ligands, which can lead to developmental defects and have been associated with many types of cancers.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / physiology*
  • ErbB Receptors / physiology*
  • Female
  • Humans
  • Male
  • Mice
  • Neoplasms / metabolism*
  • Signal Transduction / physiology*


  • Biomarkers, Tumor
  • EGFR protein, human
  • ErbB Receptors