Regulation of secondary metabolite production in filamentous ascomycetes

Mycol Res. 2008 Feb;112(Pt 2):225-30. doi: 10.1016/j.mycres.2007.08.021. Epub 2007 Sep 15.


Fungi are renowned for their ability to produce bioactive small molecules otherwise known as secondary metabolites. These molecules have attracted much attention due to both detrimental (e.g. toxins) and beneficial (e.g. pharmaceuticals) effects on human endeavors. Once the topic only of chemical and biochemical studies, secondary metabolism research has reached a sophisticated level in the realm of genetic regulation. This review covers the latest insights into the processes regulating secondary metabolite production in filamentous fungi.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Ascomycota / chemistry
  • Ascomycota / genetics*
  • Ascomycota / growth & development
  • Ascomycota / metabolism*
  • Fungal Proteins / analysis
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Gene Expression Regulation, Fungal*
  • Multigene Family
  • Mycotoxins / analysis
  • Mycotoxins / genetics
  • Mycotoxins / metabolism
  • Signal Transduction


  • Fungal Proteins
  • Mycotoxins