Supreme EnLIGHTenment: damage recognition and signaling in the mammalian UV response

Mol Cell. 2008 Feb 15;29(3):279-90. doi: 10.1016/j.molcel.2008.01.001.


Like their prokaryotic counterparts, mammalian cells can sense light, especially in the ultraviolet (UV) range of the spectrum. After UV exposure, cells mount an elaborate response--called the UV response--that mimics physiological signaling responses except that it targets multiple pathways, thereby lacking the defined specificity of receptor-triggered signal transduction. Despite many years of research, it is still not fully clear how UV radiation is sensed and converted into the "language of cells"--signal reception and transduction. This review focuses on how photonic energy and its primary cellular products are sensed to elicit the UV response.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DNA Damage / radiation effects
  • Forecasting
  • Light
  • Mammals
  • Models, Biological
  • Oxidation-Reduction
  • Proteins / metabolism
  • Signal Transduction / physiology*
  • Signal Transduction / radiation effects*
  • Ultraviolet Rays*


  • Proteins