Generation of interleukin-8 by plasmin from AVLPR-interleukin-8, the human fibroblast-derived neutrophil chemotactic factor

FEBS Lett. 1991 May 6;282(2):412-4. doi: 10.1016/0014-5793(91)80526-9.

Abstract

Plasmin mainly cleaved the Arg5-Ser6 bond of Arg-Val-Leu-Pro-Arg-interleukin-8 (AVLPR-IL-8) produced by human dermal fibroblasts, which resulted in the conversion of AVLPR-IL-8 to IL-8 and the inactive pentapeptide, though a minor cleavage of AVLPR-IL-8 by plasmin at Lys8-Glu9 bond occurred.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Assay
  • Chromatography, High Pressure Liquid
  • Fibrinolysin / metabolism*
  • Fibroblasts / metabolism*
  • Humans
  • Interleukin-8 / chemistry
  • Interleukin-8 / metabolism*
  • Molecular Sequence Data
  • Peptides / chemistry
  • Protein Precursors / metabolism
  • Rats

Substances

  • Interleukin-8
  • Peptides
  • Protein Precursors
  • Fibrinolysin