Of mice and (wo)men: is this any way to test a new drug?

J Clin Oncol. 2008 Feb 20;26(6):830-2. doi: 10.1200/JCO.2007.14.9062.
No abstract available

Publication types

  • Editorial
  • Comment

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Biomarkers, Tumor / metabolism*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / surgery
  • ErbB Receptors / drug effects
  • ErbB Receptors / metabolism
  • Erlotinib Hydrochloride
  • Female
  • Humans
  • Ki-67 Antigen / drug effects
  • Ki-67 Antigen / metabolism
  • Mice
  • Neoadjuvant Therapy / methods
  • Neoplasms, Hormone-Dependent / drug therapy*
  • Neoplasms, Hormone-Dependent / surgery
  • Protein Kinase Inhibitors / pharmacology
  • Protein Kinase Inhibitors / therapeutic use*
  • Protein-Tyrosine Kinases / antagonists & inhibitors*
  • Quinazolines / pharmacology
  • Quinazolines / therapeutic use*
  • Receptor, ErbB-2 / drug effects
  • Receptor, ErbB-2 / metabolism
  • Xenograft Model Antitumor Assays

Substances

  • Antineoplastic Agents
  • Biomarkers, Tumor
  • Ki-67 Antigen
  • Protein Kinase Inhibitors
  • Quinazolines
  • Erlotinib Hydrochloride
  • ERBB2 protein, human
  • ErbB Receptors
  • Protein-Tyrosine Kinases
  • Receptor, ErbB-2