[A case of long-term survival of postoperative brain metastasis of small cell lung cancer effectively treated with chemotherapy, whole brain radiotherapy and stereotactic radiosurgery]

Gan To Kagaku Ryoho. 2008 Feb;35(2):331-4.
[Article in Japanese]


A 63-year-old woman underwent right upper lobectomy for small cell carcinoma. She received a total of 2 courses of carboplatin and etoposide infusion as adjuvant therapy. One year after the operation, because of elevated serum Pro GRP levels and a metastatic brain tumor revealed by CT, 4 courses of IP therapy (irinotecan 60 mg/m(2), day 1, 8, 15 and cisplatin 60 mg/m(2), day 1, every 4 weeks) and whole brain radiotherapy (2 Gy f, 5 f/week, total 40 Gy) were given. A complete response was obtained, but a tumor relapse occurred ten months after the last chemotherapy. We then performed a stereotactic radiosurgery (marginal dose: 22 Gy, maximum dose 44 Gy), and one month later MRI showed the tumor had shrunk markedly. FDG-PET showed no intensive uptake, suggesting that there was no remaining viable tumor. No severe side effects were observed during these treatments. Currently, the patient has been alive with good performance status and no signs of relapse.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / radiotherapy*
  • Brain Neoplasms / secondary
  • Brain Neoplasms / surgery
  • Camptothecin / analogs & derivatives
  • Camptothecin / therapeutic use
  • Carcinoma, Small Cell / drug therapy
  • Carcinoma, Small Cell / pathology*
  • Carcinoma, Small Cell / surgery
  • Cisplatin / therapeutic use
  • Etoposide / therapeutic use
  • Female
  • Humans
  • Irinotecan
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / surgery
  • Magnetic Resonance Imaging
  • Middle Aged
  • Radiosurgery*
  • Time Factors
  • Tomography, X-Ray Computed


  • Etoposide
  • Irinotecan
  • Cisplatin
  • Camptothecin