Microenvironmental regulation of cancer development

Curr Opin Genet Dev. 2008 Feb;18(1):27-34. doi: 10.1016/j.gde.2007.12.006. Epub 2008 Feb 20.


Numerous studies have demonstrated that the tumor microenvironment not only responds to and supports carcinogenesis, but also actively contributes to tumor initiation, progression, and metastasis. During tumor progression all cells composing the tumor undergo phenotypic and epigenetic changes. Paracrine signaling between epithelial and stromal cells is important for the regulation of the proliferation, invasive, angiogenic, and metastatic behavior of cancer cells. Better understanding the molecular mechanisms by which stromal cells exert these effects may open up new venues for cancer therapeutic and preventative interventions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Carcinoma in Situ / pathology
  • Disease Progression
  • Epigenesis, Genetic
  • Epithelial Cells / metabolism
  • Humans
  • Neoplasms / etiology*
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Phenotype
  • Signal Transduction
  • Stromal Cells / metabolism