Henoch-Schonlein purpura with high factor VIII levels and deep venous thrombosis: an association or coincidence?

Rheumatol Int. 2008 Jul;28(9):935-7. doi: 10.1007/s00296-008-0542-7. Epub 2008 Feb 19.


Henoch-Schonlein purpura (HSP) is the most common systemic vasculitis in children. Although long-term outcome is generally good, serious complications may occur. Thrombosis has been reported only as an extremely rare complication of HSP. Here, we describe a 15-year-old-boy with features of HSP, who developed left main iliac, external iliac and femoral vein thrombosis. Factor VIII (FVIII) and homocystein levels were found to be high. This suggests that HSP itself may lead to a prothrombotic state and increase the risk of developing thrombosis in patients who have any risk factors.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Coagulation Protein Disorders / complications*
  • Factor VIII*
  • Femoral Vein / pathology
  • Humans
  • Iliac Vein / pathology*
  • Male
  • Purpura, Schoenlein-Henoch / complications*
  • Venous Thrombosis / complications*


  • Factor VIII