Abstract
The effects of schisandrin B (Sch B) on liver and serum lipid contents were investigated in mice with experimentally-induced hypercholesterolaemia. Hypercholesterolaemia was induced either by oral administration of a cholesterol/bile salts mixture (2/0.5 g kg(-1)) for four days or by feeding a high fat/cholesterol/bile salts (10/1/0.3%, w/w) diet for seven days. Daily co-administration of Sch B (50-200 mg kg(-1), i.g.) for four or six days, respectively, decreased hepatic total cholesterol (TC) and triglyceride (TG) levels (by up to 50% and 52%, respectively) in hypercholesterolaemic mice. Sch B treatment also increased hepatic indices (14-84%) in hypercholesterolaemic mice. The results indicated that Sch B treatment could decrease hepatic TC and TG levels, and increase liver weight, in mouse models of hypercholesterolaemia. Fenofibrate treatment (100 mg kg(-1)) produced effects similar to those of Sch B on the hepatic index and lipid levels of hypercholesterolaemic mice.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bile Acids and Salts / toxicity
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Cholesterol / metabolism
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Cholesterol, Dietary / toxicity
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Cyclooctanes / administration & dosage
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Cyclooctanes / isolation & purification
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Cyclooctanes / pharmacology
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Fatty Liver / drug therapy*
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Fatty Liver / etiology
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Fatty Liver / pathology
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Fenofibrate / pharmacology
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Hypercholesterolemia / complications
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Hypercholesterolemia / drug therapy*
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Hypolipidemic Agents / isolation & purification
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Hypolipidemic Agents / pharmacology*
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Lignans / administration & dosage
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Lignans / isolation & purification
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Lignans / pharmacology*
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Liver / drug effects
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Liver / pathology
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Male
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Mice
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Mice, Inbred ICR
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Polycyclic Compounds / administration & dosage
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Polycyclic Compounds / isolation & purification
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Polycyclic Compounds / pharmacology*
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Schisandra / chemistry*
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Triglycerides / metabolism
Substances
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Bile Acids and Salts
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Cholesterol, Dietary
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Cyclooctanes
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Hypolipidemic Agents
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Lignans
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Polycyclic Compounds
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Triglycerides
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schizandrin B
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Cholesterol
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Fenofibrate