A careful disorderliness in the proteome: sites for interaction and targets for future therapies

FEBS Lett. 2008 Apr 9;582(8):1271-5. doi: 10.1016/j.febslet.2008.02.027. Epub 2008 Feb 20.


The community of scientists interested in studying intrinsically unstructured (or disordered) proteins has emerged in recent years. What began as a controversial idea has become an established phenomenon. The new, greater focus on proteins that are in some way normally unstructured promises to provide a greater understanding of protein function, particularly with respect to protein-protein interactions. These regions also offer new possibilities into how interactions can be targeted by small molecules.

Publication types

  • Review

MeSH terms

  • Proteomics*
  • Therapeutics*