Regulation of DNA repair throughout the cell cycle

Nat Rev Mol Cell Biol. 2008 Apr;9(4):297-308. doi: 10.1038/nrm2351. Epub 2008 Feb 20.


The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint-arrested cells resume cell-cycle progression once damage has been repaired, whereas cells with unrepairable DNA lesions undergo permanent cell-cycle arrest or apoptosis. Recent studies have provided insights into the mechanisms that contribute to DNA repair in specific cell-cycle phases and have highlighted the mechanisms that ensure cell-cycle progression or arrest in normal and cancerous cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Cycle*
  • DNA Damage
  • DNA Repair*
  • Humans
  • Protein Kinases / metabolism
  • Small Ubiquitin-Related Modifier Proteins / metabolism
  • Ubiquitination


  • Small Ubiquitin-Related Modifier Proteins
  • Protein Kinases