The relationship between tumor cell differentiation and age at diagnosis in retinoblastoma

J Pediatr Ophthalmol Strabismus. Jan-Feb 2008;45(1):22-5. doi: 10.3928/01913913-20080101-16.

Abstract

Purpose: To determine the relationship between tumor cell differentiation and age at diagnosis in retinoblastoma.

Methods: Medical records of 170 patients with retinoblastoma treated by enucleation were reviewed retrospectively. Age at diagnosis and histopathological features were analyzed.

Results: Well-differentiated tumors presented earlier than poorly differentiated tumors. The frequency of presentation was highest in the first year of age for well-differentiated tumors and in the third year of age for poorly differentiated tumors (P < .0001). Bilateral well-differentiated tumors presented earlier than bilateral poorly differentiated tumors. Similarly, unilateral well-differentiated tumors presented earlier than unilateral poorly differentiated tumors.

Conclusions: Differentiated tumors present earlier than poorly differentiated tumors, irrespective of laterality in retinoblastoma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Distribution
  • Cell Differentiation*
  • Child
  • Child, Preschool
  • Eye Enucleation
  • Humans
  • Infant
  • Retinal Neoplasms / pathology*
  • Retinoblastoma / pathology*
  • Retrospective Studies