Mitigating mutational meltdown in mammalian mitochondria

PLoS Biol. 2008 Feb;6(2):e35. doi: 10.1371/journal.pbio.0060035.


Animal mitochondrial genomes have high rates of sequence evolution, and should decay from the accumulation of deleterious mutations. But the purging of mutant mtDNAs in a pedigree of "mutator mice" reveals the speed and power of purifying selection to maintain mitochondrial function.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Mammals / genetics*
  • Mitochondria / metabolism*
  • Mutation*
  • Polymorphism, Genetic