Apolipoprotein E knockout models

Curr Pharm Des. 2008;14(4):338-51. doi: 10.2174/138161208783497769.


Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they develop atherosclerosis in a short time. The current review considers lipid metabolism and inflammation as well as nutritional and pharmacological agents affecting atherosclerosis, using the apo E knock out mouse model.

Publication types

  • Review

MeSH terms

  • Animals
  • Apolipoproteins E / deficiency*
  • Apolipoproteins E / genetics
  • Apolipoproteins E / metabolism
  • Atherosclerosis / genetics
  • Atherosclerosis / metabolism*
  • Atherosclerosis / therapy*
  • Disease Models, Animal*
  • Genetic Therapy / methods
  • Humans
  • Mice
  • Mice, Knockout
  • Protein Binding / genetics


  • Apolipoproteins E