Taip2 is a novel cell death-related gene expressed in the brain during development

Biochem Biophys Res Commun. 2008 May 2;369(2):426-31. doi: 10.1016/j.bbrc.2008.02.041. Epub 2008 Feb 20.


TAIP2 was isolated as one of the homologous genes of TAIP3 (TGF-beta-up-regulated apoptosis-inducing-protein chromosome 3). The transcript of the mouse counterpart of TAIP2, designated mTaip2, was detected in several tissue specimens from embryos to adults, while mTaip2 was dominantly expressed in the embryonic brain. The overexpression of the full-length mTaip2 induced cell death in various cell lines. An analysis of mTaip2 deletion mutants revealed that the N-terminal half of mTaip2, but not the C-terminal half, had nuclear localization and cell death-inducing activities. The results indicate that mTaip2 is a novel cell death-related gene dominantly expressed in the embryonic brain, thus suggesting that mTaip2 may play a role in development of the brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / metabolism*
  • Animals
  • Apoptosis / physiology*
  • Apoptosis Regulatory Proteins / metabolism*
  • Brain / embryology*
  • Brain / physiology*
  • Cells, Cultured
  • DNA-Binding Proteins
  • Gene Expression Regulation, Developmental / physiology*
  • Mice
  • Nerve Tissue Proteins / metabolism*
  • Nuclear Proteins / metabolism*
  • Organ Specificity
  • Tissue Distribution


  • Apoptosis Regulatory Proteins
  • DNA-Binding Proteins
  • Nerve Tissue Proteins
  • Nuclear Proteins
  • Taip2 protein, mouse