Targeting the bacterial Z-ring

Chem Biol. 2008 Feb;15(2):93-4. doi: 10.1016/j.chembiol.2008.02.001.

Abstract

FtsZ is a prokaryotic homolog of eukaryotic tubulin and forms the essential bacterial cell division ring (Z-ring). A new study in this issue of Chemistry & Biology, Läppchen et al., provides further evidence that differences in nucleotide-binding properties of FtsZ and tubulin can be exploited to specifically target the bacterial Z-ring.

Publication types

  • Comment

MeSH terms

  • Anti-Infective Agents / pharmacology
  • Bacteria / cytology*
  • Bacteria / drug effects*
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / metabolism*
  • Cell Division / drug effects
  • Cytoskeletal Proteins / chemistry
  • Cytoskeletal Proteins / metabolism*
  • Drug Design
  • Models, Molecular
  • Nucleotides / metabolism
  • Protein Structure, Tertiary
  • Sensitivity and Specificity
  • Tubulin / chemistry
  • Tubulin / metabolism

Substances

  • Anti-Infective Agents
  • Bacterial Proteins
  • Cytoskeletal Proteins
  • FtsZ protein, Bacteria
  • Nucleotides
  • Tubulin