Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 33 (3), 141-50

Stress Granules: The Tao of RNA Triage

Affiliations
Review

Stress Granules: The Tao of RNA Triage

Paul Anderson et al. Trends Biochem Sci.

Abstract

Cytoplasmic RNA structures such as stress granules (SGs) and processing bodies (PBs) are functional byproducts of mRNA metabolism, sharing substrate mRNA, dynamic properties and many proteins, but also housing separate components and performing independent functions. Each can exist independently, but when coordinately induced they are often tethered together in a cytosolic dance. Although both self-assemble in response to stress-induced perturbations in translation, several recent reports reveal novel proteins and RNAs that are components of these structures but also perform other cellular functions. Proteins that mediate splicing, transcription, adhesion, signaling and development are all integrated with SG and PB assembly. Thus, these ephemeral bodies represent more than just the dynamic sorting of mRNA between translation and decay.

Similar articles

See all similar articles

Cited by 459 PubMed Central articles

See all "Cited by" articles

Publication types

LinkOut - more resources

Feedback