Inflammation and cancer: role of nuclear factor-kappaB activation

Cancer Sci. 2008 May;99(5):836-42. doi: 10.1111/j.1349-7006.2008.00763.x. Epub 2008 Feb 24.


It has been thought that there is a strong relationship between inflammation and carcinogenesis so that the development of cancer occurs with chronic inflammation in many organs. An in-depth understanding of the mechanism by which inflammation can lead to carcinogenesis may enable the development of drugs targeted at important molecules, providing a powerful tool for preventing cancer development. In this review, we focused on a signal transduction system, the nuclear factor-kappaB (NF-kappaB) pathway, which is thought to play a role in the process leading from inflammation to carcinogenesis, and may thus serve as a candidate for targeted intervention.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic
  • Humans
  • Inflammation / metabolism*
  • Liver Neoplasms / metabolism
  • Models, Biological
  • NF-kappa B / metabolism*
  • Neoplasms / immunology
  • Neoplasms / metabolism*
  • Signal Transduction
  • Stomach Neoplasms / metabolism


  • NF-kappa B