The importance of left ventricular function for long-term outcome after primary percutaneous coronary intervention

BMC Cardiovasc Disord. 2008 Feb 23;8:4. doi: 10.1186/1471-2261-8-4.


Background: In the present study we sought to determine the long-term prognostic value of left ventricular ejection fraction (LVEF), assessed by planar radionuclide ventriculography (PRV), after ST-elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (PPCI).

Methods: In total 925 patients underwent PRV for LVEF assessment after PPCI for myocardial infarction before discharge from the hospital. PRV was performed with a standard dose of 500 Mbq of 99mTc-pertechnetate. Average follow-up time was 2.5 years.

Results: Mean (+/- SD) age was 60 +/- 12 years. Mean (+/- SD) LVEF was 45.7 +/- 12.2 %. 1 year survival was 97.3 % and 3 year survival was 94.2 %. Killip class, multi vessel-disease, previous cardiovascular events, peak creatin kinase and its MB fraction, age and LVEF proved to be univariate predictors of mortality. When entered in a forward conditional Cox regression model age and LVEF were independent predictors of 1 and 3 year mortality.

Conclusion: LVEF assessed by PRV is a powerful independent predictor of long term mortality after PPCI for STEMI.

MeSH terms

  • Aged
  • Angioplasty, Balloon, Coronary*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / epidemiology
  • Myocardial Infarction / mortality*
  • Myocardial Infarction / physiopathology
  • Myocardial Infarction / therapy
  • Prognosis
  • Proportional Hazards Models
  • Radionuclide Ventriculography
  • Registries
  • Risk Factors
  • Stroke Volume*
  • Ventricular Function, Left*