Abstract
2-Modified aristeromycin derivatives and their related analogs were synthesized to investigate their inhibitory activity against human and Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase (PfSAHH). 2-Fluoroaristeromycin showed a strong inhibitory activity against PfSAHH selectively and complete resistance to adenosine deaminase.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine / analogs & derivatives*
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Adenosine / chemical synthesis
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Adenosine / chemistry
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Adenosine / pharmacology
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Adenosylhomocysteinase / antagonists & inhibitors*
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Adenosylhomocysteinase / metabolism
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Animals
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Antimalarials / chemical synthesis*
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Antimalarials / chemistry
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Antimalarials / pharmacology*
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Molecular Structure
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / enzymology*
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Structure-Activity Relationship
Substances
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Antimalarials
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Enzyme Inhibitors
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aristeromycin
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Adenosylhomocysteinase
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Adenosine