Stems cells and the pathways to aging and cancer

Cell. 2008 Feb 22;132(4):681-96. doi: 10.1016/j.cell.2008.01.036.


The aging of tissue-specific stem cell and progenitor cell compartments is believed to be central to the decline of tissue and organ integrity and function in the elderly. Here, we examine evidence linking stem cell dysfunction to the pathophysiological conditions accompanying aging, focusing on the mechanisms underlying stem cell decline and their contribution to disease pathogenesis.

Publication types

  • Review

MeSH terms

  • Aged
  • Aging / metabolism*
  • Animals
  • Cellular Senescence
  • Humans
  • Neoplasms / metabolism*
  • Signal Transduction*
  • Stem Cells / metabolism*