Antimicrobial prophylaxis for wounds and procedures in the emergency department

Infect Dis Clin North Am. 2008 Mar;22(1):117-43, vii. doi: 10.1016/j.idc.2007.12.002.


Emergency physicians are often confronted with situations in which a patient with an acute injury is at high risk for an infection. Although most traumatic wounds have a low risk for developing infection, certain types of high-risk trauma justify antimicrobial prophylaxis. This article reviews antimicrobial wound infection prophylaxis for high-risk traumatic wounds, including the prevention of rabies and tetanus. Prophylaxis to prevent infections related to invasive procedures in the emergency department is also addressed.

Publication types

  • Review

MeSH terms

  • Anti-Infective Agents / therapeutic use*
  • Antibiotic Prophylaxis / methods*
  • Bacterial Infections / drug therapy
  • Bacterial Infections / prevention & control*
  • Emergency Medicine / methods*
  • Humans
  • Rabies / drug therapy
  • Tetanus / drug therapy
  • Tetanus / prevention & control
  • Tetanus Toxoid / therapeutic use
  • Wounds and Injuries / drug therapy*
  • Wounds and Injuries / microbiology


  • Anti-Infective Agents
  • Tetanus Toxoid