Fetal growth after laser therapy for twin-twin transfusion syndrome

Am J Obstet Gynecol. 2008 Jul;199(1):47.e1-6. doi: 10.1016/j.ajog.2007.11.062. Epub 2008 Mar 4.


Objective: The objective of the study was to compare twin weight discordance and prevalence of intrauterine growth restriction (IUGR) before laser therapy and after birth in pregnancies complicated by twin-twin transfusion syndrome (TTTS).

Study design: Women with TTTS who underwent laser therapy with dual neonatal survivors born at least 28 days after surgery were studied. Estimated fetal weight (EFW) discordance at the preoperative sonogram and birthweight (BW) discordance were calculated. Weights below gestational age-corrected 10th percentile at sonogram and at birth for each twin were designated as IUGR.

Results: Among 211 women studied, the mean EFW discordance measured 26.6% and mean BW discordance was 18.4%, yielding a mean 8.2% decrease in weight discordance (P < .001). Comparing IUGR diagnoses before surgery and at birth, the recipient's proportion was unchanged (9.5% vs 7.1%, P = .353), whereas the donor's proportion decreased (64.5% vs 28.9%, P < .001).

Conclusion: Twin weight discordance and donor fetus IUGR appear to improve after laser therapy for TTTS.

Publication types

  • Comparative Study
  • Twin Study

MeSH terms

  • Adult
  • Birth Weight
  • Female
  • Fetal Development*
  • Fetal Growth Retardation / epidemiology
  • Fetal Weight
  • Fetofetal Transfusion / surgery*
  • Gestational Age
  • Humans
  • Laser Therapy*
  • Pregnancy
  • Pregnancy Outcome
  • Prevalence
  • Ultrasonography, Prenatal*